A man has been charged with the murder of Irish vet Catherine Gowing, whose burnt-out car was found earlier on Friday.
Clive Sharpe, 46, from Bethesda, Gwynedd, will appear before Mold magistrates on Saturday morning, the Crown Prosecution Service said (CPS).
Ms Gowing, 37, failed to arrive at work at the Evans Veterinary Practice in Mold, North Wales, on Monday.
She was captured on CCTV at an Asda store in Queensferry, Flintshire, at 8:06pm last Friday night.
Karen Dixon, district crown prosecutor for the CPS in Wales, told a news conference on Friday: "We have concluded that there is sufficient evidence to charge Clive Sharpe with the murder of Catherine Gowing and that it is in the public interest to do so."
Earlier on Friday, police confirmed a burnt out Renault Clio found at a disused quarry in Pinfold Lane, Alltami, near Mold, was hers.
Detective Superintendent John Hanson, who is leading the investigation for North Wales Police, renewed his appeal for witnesses.
He said: "I have already spoken about the extent and scope of the examinations and searches taking place and the resources involved in the search to find Catherine.
"Those searches will continue into this evening and throughout the weekend.
"We will do all that is conceivably possible to find Catherine and return her to her family. They are aware of this significant development and they are fully updated on progress of the investigation."
He added that dog teams and underwater search officers were involved in the operation and that two other undisclosed locations were being examined.
Anyone with information should call North Wales police on 101.